What is Sodium cyanoborohydride CAS 25895-60-7

The chemical formula of sodium cyanoborohydride, usually referred to as sodium cyanoborohydride or CAS 25895-60-7, is NaBH3CN.It is a moderate yet efficient reducing agent that works well for reducing carbonyl compounds to their corresponding alcohols, such as aldehydes and ketones.

Product Parameter

Synonyms

SodiuM cyanohydridoborate; Sodium cyanoborohydride, 1M solution in THF, AcroSeal; (cyano-C)trihydro-,sodium,(T-4)-Borate(1-); SodiuM (T-4)-(Cyano-C)trihydroborate(1-); sodium,(beta-4)-borate(1-(cyano-c)trihydro-; Sodium cyanoborohydride,Sodium cyanotrihydridoborate; Sodium Cyanotrihydridoborate; Sodium cyanotrihydroborate(1-); Borate(1-), (cyano-κC)trihydro-, sodium, (T-4)-; Sodium cyanotrihydroborate; Sodium borocyanohydride; Sodium cyanoboranuide; Borate(1-), cyanotrihydro-, sodium; Borate(1-), (cyano-κC)trihydro-, sodium (1:1), (T-4)-; Borate(1-), (cyano-C)trihydro-, sodium, (T-4)-; Sodium cyanoboronhydride; Sodium cyanoborohydride, 1M solution in THF, AcroSeal§3;

Sodium cyanoborohydride application

The following are some uses for sodium cyanoborohydride:
1. As a moderate reducing agent:

• Carbonyl compounds, such as aldehydes and ketones, are frequently reduced to their corresponding alcohols by sodium cyanoborohydride.
• Reductive amination is a common method of synthesising amines using sodium cyanoborohydride.
  Sodium cyanoborohydride has a milder reactivity than other stronger reducing agents like lithium aluminium hydride (LiAlH4) or sodium borohydride (NaBH4).

2. Stabilization of antibodies: In biochemistry and immunology, sodium cyanoborohydride is used to stabilize antibodies by decreasing and obstructing unreacted aldehyde groups on the antibody’s surface. This prevents non-specific binding and increases the antibody’s stability in a range of applications, including immunohistochemistry and immunoassays.
3. By producing hydrogen on-site, it makes hydrogenation reactions easier and eliminates the requirement for high-pressure hydrogen gas.