Revealing the capabilities of 2-Bromo-4-Methylpropiophenone: An essential compound in the field of chemistry!

2-Bromo-4-methylpropiophenone (CAS 1451-82-7) is an intriguing chemical in the realm of organic chemistry. It has the molecular formula C10H11Bro and is capable of dissolving in chloroform and methanol. This compound exhibits distinct characteristics as a solid or powder, appearing as a white to off-white substance. It is frequently employed as an intermediary and unprocessed substance in the production of high-quality compounds. Now, let’s get into the different facets of this product.

Analysing the Chemical Composition of 2-Bromo-4-Methylpropiophenone

2-Bromo-4-methylpropiophenone belongs to the phenylacetone group, hence we will now examine its chemical properties.

1. Molecular structure:

CAS 1451-82-7 is composed of a phenyl group (C6H5) connected to the main chain of phenylacetone (C6H5COCH2CH3), a bromine atom (Br) substituted at the 2-position, and a methyl group (CH3) substituted at the 4-position of the phenyl group.

2. primary function:

a. The primary structure of phenylacetone consists of a ketone functional group (C=O), which is accountable for its reactivity in diverse chemical processes.
b. The presence of a bromine atom in a chemical from the bromine group (Br) enhances its reactivity and alters its characteristics, allowing it to be effectively used in organic synthesis.
c. Methyl groups (CH3) contribute to steric hindrance and can influence the chemical reactivity and physical characteristics of molecules.

cas 1451-82-7 Molecular Formulae

Synthesis and Production

The typical procedure for synthesising 2-bromo-4-methylpropiophenone entails the bromination of 4-methylacetophenone, which is also referred to as p-tolyl methyl ketone. Below is a concise overview of the synthesis process:

1. The bromination process involves the addition of a bromine atom to 4-methylacetophenone. This reaction is typically performed using either bromine (Br2) or N-bromosuccinimide (NBS) as the brominating agent. A suitable solvent and maybe a catalyst are used in this reaction. The reaction is often conducted with precise control to guarantee the specific bromination at the intended location.

2. Selective bromination: The bromine atom (Br) is specifically added to the 2-position of the benzene ring because of the presence of the methyl group (CH3) at the 4-position. Ensuring selectivity is crucial for achieving a high yield and purity of the intended product, 2-bromo-4-methylpropiophenone.

3. Post-treatment and purification: After the bromination reaction is finished, the reaction mixture is typically stopped and the impure product is isolated through a sequence of post-treatment procedures, which may involve extraction, filtration, and purification methods like recrystallization or chromatography. These procedures aid in the elimination of impurities and by-products in order to get a refined product of CAS 1451-82-7.

4. Characterisation and analysis of the synthesised 2-bromo-4-methylpropiophenone involves the use of various analytical techniques, including nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy, and mass spectrometry. These techniques are employed to confirm the purity and identity of the product and to ensure that it meets the necessary quality standards.

5. Scaling up and manufacturing: After establishing and optimising the synthesis pathway on a small laboratory scale, the production of 2-bromo-4-methylpropiophenone can be increased to industrial levels. Mass manufacturing can encompass either batch or continuous methods and may necessitate extra safety precautions.

To summarise, the process of synthesising 2-bromo-4-methylpropiophenone (CAS 1451-82-7) entails the targeted introduction of a bromine atom to 4-methylacetophenone, followed by subsequent treatment, purification, and characterization procedures to provide the desired end product.

Physical and Chemical Properties

1. In the pharmaceutical sector, 2-Bromo-4-methylpropiophenone is utilised as a crucial step in the synthesis of several medicinal molecules. It has the ability to undergo various intricate chemical interactions, leading to the formation of diverse compounds. Additionally, it plays a crucial role in the production of medications that possess multiple therapeutic properties.

2. Agriculture: 2-Bromo-4-methylpropiophenone serves as a fundamental component in the production of agrochemicals, such as herbicides, insecticides, and fungicides.

3. Fine chemicals: 2-Bromo-4-methylpropiophenone is utilised in the synthesis of fine chemicals, such as specialty chemicals and intermediates employed in the creation of flavours, perfumes, and other valuable items.

4. Research and development: 2-Bromo-4-methylpropiophenone is utilised in research laboratories for the purpose of advancing chemical processes, creating novel chemicals, and investigating reaction mechanisms. The fact that it is readily available as a starting material makes it easier to study and experiment with different chemical reactions.

2-bromo-4-methylpropiophenone is an essential intermediate in organic synthesis, playing a crucial role in the manufacturing of medicines, agrochemicals, fine chemicals, and other substances. The valuable attributes of its adaptability and responsiveness render it highly useful in a wide range of scientific and industrial applications.

Precautions for Safety and Handling

While 2-bromo-4-methylpropiophenone has promising potential for several applications, it is important to use caution when handling and using this compound. To mitigate the dangers associated with exposure, storage, and disposal, it is imperative to adhere to the necessary safety standards when dealing with any chemical substance. Safe handling procedures include sufficient ventilation, the use of personal protection equipment (PPE), and strict adherence to established safety norms.


2-bromo-4-methylpropiophenone (CAS 1451-82-7) is a chemical that is very flexible and essential, with a wide range of uses in various sectors. Due to its distinctive chemical composition, as well as its reactivity and characteristics, it serves as a crucial precursor for organic synthesis, medicines, agrochemicals, and research.

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